Table 2. Individual data of included patients.

	Age	Immuno-suppressive drugs	Immuno-deficiency disease	IgA (g/l)	Baseline IgG (g/l)	IgG nadir value under IVIG/SCIG (g/l)	Monthly dose IVIG/SCIG	Vaccine	Time from 2. vaccine to blood analysis (d)	SARS-CoV-2-IgG spike protein (AU/ml)
1	73	No	CVID	<0.05	0.07	8.3	30	BNT162b2	71	<12
2	51	No	CVID	0.07	0.7	7.2	50	mRNA-1273	22	<12
3	55	No	CVID	<0.05	0.8	13.4	28	BNT162b2	39	<12
4	56	No	CVID	1.67	1.9	6.7	25	BNT162b2	40	125
5	57	No	CVID	0.07	1.9	8.2	40	BNT162b2	76	<12
6	56	No	CVID	0.06	3.1	8.2	30	BNT162b2	66	>400
7	72	Ibrutinib / rituximab	secondary	0.7	3.2	10.6	25	mRNA-1273	22	<12
8	86	No	CVID	0.32	3.4	4.9	10	BNT162b2	59	20.4
9	61	No	CVID	<0.05	3.5	10.2	25	BNT162b2	49	14.4
10	49	No	CVID	0.47	3.6	10.6	24	BNT162b2	74	99.9
11	26	No	CVID	0.54	3.8	7.2	70	BNT162b2	22	>400
12	78	Rituximab	CVID	0.49	4.2	8.0	25	BNT162b2	88	<12
13	54	Certolizumab	IgG deficiency	0.83	4.2	6.8	25	BNT162b2	28	37
14	69	No	CVID	11.15	4.3	8.7	25	mRNA-1273	40	372
15	84	No	CVID	0.57	4.3	9.1	30	BNT162b2	112	<12
16	62	Etanercept	IgG deficiency	0.8	4.4	11.4	40	BNT162b2	24	<12
17	74	No	CVID	0.3	4.5	9.3	20	mRNA-1273	63	276
18	86	Rituximab	CVID	<0.05	4.7	8.4	25	BNT162b2	92	<12
19	64	No	CVID	0.53	4.8	8.9	25	BNT162b2	48	59.9
20	59	No	CVID	1.31	5.1	9.6	15	mRNA-1273	22	>400
21	72	No	CVID	1.25	5.3	8.5	50	BNT162b2	34	141
22	91	No	IgG 1 and 3 deficiency	1.23	5.6	7.3	10	BNT162b2	57	109
23	72	Ibrutinib	CVID	0.29	5.7	12	60	mRNA-1273	37	<12
24	31	No	CVID	0.42	5.9	12.1	35	BNT162b2	47	>400
25	31	No	IgG 1 and 3 deficiency	0.92	5.9	9.3	40	BNT162b2	45	>400
26	31	No	CVID	0.58	6	10.0	30	BNT162b2	14	>400
27	72	No	IgG 1 deficiency	1.7	6.1	9.2	25	BNT162b2	62	>400
28	49	No	CVID	0.4	6.2	9.9	40	BNT162b2	22	78.9
29	62	Ocrelizumab	secondary	1.16	6.3	7.8	15	mRNA-1273	33	<12
30	57	Methotrexat / prednisolone	CVID	1.26	6.3	8.3	25	BNT162b2	37	<12
31	23	No	IgG 2 deficiency	0.75	6.5	7.6	15	mRNA-1273	37	136
32	57	No	IgG 1 and 3 deficiency	2.62	6.6	9.6	20	BNT162b2	65	161
33	45	No	CVID	0.33	6.6	8.8	25	BNT162b2	39	248
34	79	No	IgG 1 deficiency	1.18	6.8	9.6	25	mRNA-1273	56	20
35	87	No	IgG 2 and 3 deficiency	2.7	7.5	8.1	10	mRNA-1273	50	>400
36	73	Mycophenolat-mofetile	CVID	0.3	8.3	15.6	30	BNT162b2	43	12.8
37	41	No	IgG 2 deficiency	0.82	8.6	11.2	20	BNT162b2	99	142
38	75	No	IgG 1 and 3 deficiency	2.49	9.1	11.5	20	BNT162b2	71	129
39	58	No	CVID	0.58	5.7	8.7	20	BNT162b2	18	<12

Laboratory reference values: IgG 7.0–16.0 g/l, IgA 0.7–4.0 g/l, SARS-CoV-2-IgG spike protein cutoff 12 AU/ml.

Common variable immunodeficiency disease (CVID), intravenous immunoglobulin substitution (IVIG), subcutaneous immunoglobulin substitution (SCIG).