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Targeting and NIR-florescence-activation mechanisms of the CLN. The cyanine fluorophore is marked in bright red in the structure of CLNH; the lysosome-targeted morpholine group is labeled in purple; the nitrobenzene groups as an NTR-response unit are marked in blue in the structure of CLN, which are reduced to amino groups after being triggered by NTR, marked in dark red in the structure of CLNH.
