Table 2.
Cytotoxic activity of the nanoemulsion formulations of the essential oils obtained from J. humile (JhEO-NE) and J. grandiflorum (JgEO-NE) as well as the reference drug doxorubicin, against HepG2, MCF-7, and THP-1 cell lines, showing CC50, IC50, and SI.
| Sample | CC50 ± SD (µg/mL) |
Cytotoxic Activity | ||||||
|---|---|---|---|---|---|---|---|---|
| HepG-2 | MCF-7 | THP-1 | ||||||
| IC50 ± SD (µg/mL) | SI | IC50 ± SD (µg/mL) | SI | IC50 ± SD (µg/mL) | SI | |||
| Media | DMSO (-Ve Control) |
NT | NA | - | NA | - | NA | - |
| Pure EOs | J. humile | 362.83 ± 15.31 | 289.10 ± 5.61 | 1.26 | 304.13 ± 3.55 | 1.19 | 265.60 ± 10.85 | 1.37 |
| J. grandiflorum | 377.33 ± 10.82 | 324.90 ± 22.85 | 1.16 | 327.53 ± 6.06 | 1.15 | 286.37 ± 7.63 | 1.32 | |
| Nano-emulsion | J. humile | 64.28 ± 4.17 | 22.58 ± 0.86 | 2.85 | 36.19 ± 0.77 | 1.78 | 51.76 ± 6.68 | 1.24 |
| J. grandiflorum | 62.42 ± 2.07 | 26.65 ± 0.06 | 2.34 | 36.09 ± 1.44 | 1.73 | 54.41 ± 0.60 | 1.15 | |
| Standard | Doxorubicin | 114.00 ± 2.17 | 33.96 ± 2.03 | 3.36 | 52.73 ± 2.44 | 2.16 | 47.98 ± 2.35 | 2.38 |
NT: Nontoxic, NA: Not active.