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. 2022 Jun 5;14(11):2351. doi: 10.3390/nu14112351

Figure 6.

Figure 6

Impact of selected hyperlipidaemia-associated single nucleotide polymorphisms (SNPs) on the development of contact allergy and hay fever. We assessed selected hyperlipidaemia-associated genetic variations in relation to allergy occurrence using BMI- and hyperlipidaemia-adjusted binomial logistic regression (odds ratios + confidence intervals, p-values, and significance levels (*: p < 0.05) are displayed corresponding to each analysis). Out of the 118 tested SNPs originating from either the PCSK9 (n = 14), LDL-R (n = 19), VLDL-R (n = 70), or apoB (n = 15) gene, 9 SNPs were directly associated to an increased prevalence of contact allergies. In detail, eight of the identified SNPs were variations in the VLDL-R and one in the PCSK9 gene (A). Regarding hay fever, two SNPs of the LDL-R and one SNP of the LDL-R showed a direct association to allergy occurrence (B). For all analyses, the wildtype was set as reference group.