Table 4.

Kinetic profiling of methotrexate patches.

F. Code	Zero order		1st Order		Higuchi		Hixon–Crowell		Korsmeyer–Peppas
	K ± SD	R2	K ± SD	R2	K ± SD	R2	K ± SD	R2	K ± SD	R2	n
F1	1.37 ± 0.012	0.968	1.28 ± 0.116	0.541	1.38 ± 0.142	0.981	1.45 ± 0.252	0.991	0.12 ± 0.321	0.985	0.798
F2	1.25 ± 0.116	0.972	1.24 ± 0.169	0.613	2.54 ± 0.227	0.985	1.32 ± 0.143	0.984	0.163 ± 0.012	0.997	0.838
F3	1.11 ± 0.154	0.989	1.18 ± 0.125	0.638	2.52 ± 0.481	0.988	1.28 ± 0.268	0.989	0.034 ± 0.158	0.991	0.764
F4	1.23 ± 0.128	0.978	1.26 ± 0.116	0.584	2.52 ± 1.214	0.991	1.34 ± 0.132	0.993	0.043 ± 0.321	0.993	0.784
F5	1.26 ± 0.148	0.983	1.84 ± 0.143	0.564	1.45 ± 0.029	0.99	1.64 ± 0.154	0.985	0.15 ± 0.148	0.995	0.784
F6	1.14 ± 0.141	0.964	1.42 ± 0.136	0.663	2.53 ± 0.124	0.976	1.37 ± 0.182	0.984	0.167 ± 0.124	0.991	0.782
F7	1.25 ± 0.213	0.981	1.31 ± 0.142	0.689	2.16 ± 0.136	0.984	1.41 ± 0.268	0.983	0.035 ± 0.132	0.994	0.804
F8	1.32 ± 0.186	0.984	1.26 ± 0.158	0.586	2.86 ± 0.006	0.991	1.46 ± 0.321	0.988	0.081 ± 0.163	0.991	0.738
F9	1.15 ± 0.124	0.986	1.15 ± 0.186	0.594	2.22 ± 0.124	0.989	1.32 ± 0.143	0.992	0.141 ± 0.183	0.994	0.752

Data are expressed as mean ± SD; n = 3.