Table 2.
Secondary endpoints results. The intragroup (vs. baseline) statistical analysis is reported near the raw data, while the intergroup (active vs. placebo) statistical analysis is reported near the % variation (Δ%). The statistical analysis is reported as follows: * p < 0.05, ** p < 0.01, and *** p < 0.005. Legend. D0, baseline; D14, follow-up visit after 15 days of product use; D57, follow-up visit after 56 days of product use. O, Overall (Asian and Caucasian subjects); A, Asian; C, Caucasian.
| Active | Placebo | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| D0 | D15 | Δ% | D57 | Δ% | D0 | D15 | Δ% | D57 | Δ% | ||
| Moist. (cu) | O | 53.7 ± 2.2 | 55.9 ± 2.2 *** | +5.3% ** | 59.3 ± 2.2 *** | +12.3% *** | 55.1 ± 2.2 | 51.6 ± 2.0 * | −3.6% | 53.2 ± 2.0 | −1.9% |
| A | 61.7 ± 2.1 | 64.3 ± 2.0 *** | +4.8% * | 67.9 ± 2.0 *** | +11.0% *** | 62.6 ± 2.3 | 58.3 ± 2.1 | −4.1% | 60.8 ± 1.9 | −1.8% | |
| C | 42.6 ± 3.3 | 44.3 ± 3.1 | +5.9% | 47.3 ± 3.0 *** | +14.2% *** | 44.7 ± 3.0 | 42.2 ± 2.8 | −2.8% | 42.8 ± 2.9 | −2.0% | |
| Rad. (au) | O | 10.9 ± 0.5 | 11.5 ± 0.5 | +9.2% | 12.5 ± 0.6 *** | +18.5% *** | 11.6 ± 0.5 | 11.6 ± 0.5 | +1.8% | 11.7 ± 0.5 | +2.5% |
| A | 10.5 ± 0.7 | 10.8 ± 0.5 | +8.0% | 12.1 ± 0.7 *** | +18.2% *** | 10.6 ± 0.6 | 10.6 ± 0.7 | +1.3% | 10.9 ± 0.7 | +2.4% | |
| C | 11.4 ± 0.9 | 12.4 ± 1.0 * | +10.9% | 13.2 ± 1.0 *** | +18.8% ** | 13.0 ± 0.9 | 12.9 ± 0.7 | +2.5% | 12.9 ± 0.7 | +2.4% | |
| ITA° | O | 23.0 ± 1.3 | 25.7 ± 1.4 *** | +14.8% | 29.3 ± 1.5 *** | +32.9% *** | 23.5 ± 1.1 | 24.3 ± 1.2 | +6.8% | 25.7 ± 1.2 ** | +12.5% |
| A | 23.4 ± 1.8 | 26.1 ± 2.0 *** | +15.3% | 29.7 ± 2.1 *** | +33.2% ** | 24.1 ± 1.7 | 25.0 ± 1.8 | +7.4% | 26.4 ± 1.9 * | +13.2% | |
| C | 22.4 ± 1.7 | 25.2 ± 2.0 | +14.1% *** | 28.9 ± 2.1 *** | +32.4% ** | 22.8 ± 1.4 | 23.2 ± 1.3 | +5.8% | 24.7 ± 1.4 * | +11.5% | |
| TEWL (g/h/m2) | O | 12.7 ± 0.5 | 12.2 ± 0.4 | −2.7% ** | 10.8 ± 0.4 *** | −14.5% ** | 12.2 ± 0.5 | 12.9 ± 0.5 | +8.0% | 12.6 ± 0.4 | +4.8% |
| A | 13.3 ± 0.7 | 12.5 ± 0.5 | −4.0% * | 11.2 ± 0.5 *** | −14.3% *** | 13.2 ± 0.7 | 13.7 ± 0.6 | +6.4% | 13.4 ± 0.6 | +3.5% | |
| C | 11.9 ± 0.6 | 11.7 ± 0.6 | −1.0% | 10.1 ± 0.6 *** | −14.9% *** | 10.9 ± 0.5 | 11.9 ± 0.7 | +10.3% | 11.4 ± 0.5 | +6.6% | |
| Wr. depth (μm) | O | 349.8 ± 14.1 | 350.4 ± 14.4 | +0.1% | 325.0 ± 13.4 *** | −6.9% *** | 345.7 ± 16.7 | 347.8 ± 16.7 | +0.8% | 349.1 ± 16.5 | +1.4% |
| A | 291.0 ± 9.5 | 289.3 ± 9.9 | −0.6% | 269.9 ± 10.3 *** | −7.5% *** | 277.3 ± 12.8 | 282.7 ± 13.3 * | +2.0% | 281.1 ± 12.4 | +1.8% | |
| C | 431.6 ± 21.5 | 435.4 ± 21.4 | +1.1% | 401.6 ± 19.5 ** | −6.2% ** | 440.9 ± 24.7 | 438.4 ± 25.4 | −0.8% | 443.7 ± 24.5 | +0.8% | |
Moist, Skin moisturization; Rad, Skin radiance; ITA°, Individual Typology Angle; Wr. depth, wrinkle depth.