Table 3.
Active | Placebo | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
D0 | D15 | Δ% | D57 | Δ% | D0 | D15 | Δ% | D57 | Δ% | ||
R0 (mm) | O | 0.321 ± 0.013 | 0.294 ± 0.012 *** | −8.2% *** | 0.269 ± 0.011 *** | −15.6% | 0.322 ± 0.013 | 0.327 ± 0.013 * | +2.0% | 0.330 ± 0.014 | +3.1% |
A | 0.257 ± 0.006 | 0.254 ± 0.006 *** | −9.3% *** | 0.215 ± 0.007 *** | −15.2% *** | 0.251 ± 0.007 | 0.257 ± 0.008 | +2.5% | 0.260 ± 0.010 | +3.8% | |
C | 0.413 ± 0.017 | 0.384 ± 0.014 ** | −6.5% *** | 0.343 ± 0.012 *** | −16.0% *** | 0.420 ± 0.012 | 0.425 ± 0.013 | +1.2% | 0.429 ± 0.014 | +3.8% | |
R2 (%) | O | 0.593 ± 0.015 | 0.626 ± 0.016 *** | +5.9% *** | 0.671 ± 0.015 *** | +13.9% *** | 0.582 ± 0.013 | 0.583 ± 0.013 | +0.1% | 0.577 ± 0.014 | −0.9% |
A | 0.520 ± 0.010 | 0.551 ± 0.010 *** | +6.2% *** | 0.598 ± 0.011 *** | +15.5% *** | 0.522 ± 0.010 | 0.523 ± 0.011 | 0.0% | 0.518 ± 0.014 | −0.9% | |
C | 0.695 ± 0.017 | 0.730 ± 0.018 ** | +5.5% ** | 0.773 ± 0.018 *** | +11.6% *** | 0.665 ± 0.014 | 0.667 ± 0.014 | +0.2% | 0.0659 ± 0.015 | −0.8% | |
R5 (%) | O | 0.449 ± 0.016 | 0.514 ± 0.018 *** | +16.8% *** | 0.587 ± 0.022 *** | +33.4% *** | 0.447 ± 0.016 | 0.438 ± 0.017 | −2.6% | 0.441 ± 0.016 | −1.2% |
A | 0.504 ± 0.012 | 0.579 ± 0.016 *** | +15.9% *** | 0.668 ± 0.019 *** | +34.3% *** | 0.500 ± 0.011 | 0.485 ± 0.015 | −3.1% | 0.491 ± 0.015 | −1.8% | |
C | 0.372 ± 0.025 | 0.424 ± 0.025 ** | +17.1% *** | 0.475 ± 0.029 *** | +31.0% *** | 0.375 ± 0.024 | 0.372 ± 0.026 | −1.3% | 0.372 ± 0.024 | −0.6% | |
R9 (mm) | O | 0.040 ± 0.001 | 0.035 ± 0.001 *** | −12.1% *** | 0.030 ± 0.001 *** | −25.4% *** | 0.039 ± 0.001 | 0.041 ± 0.002 | 6.5% | 0.041 ± 0.002 | +5.9% |
A | 0.039 ± 0.002 | 0.034 ± 0.002 *** | −12.1% *** | 0.029 ± 0.002 *** | −25.8% *** | 0.039 ± 0.001 | 0.042 ± 0.002 * | +10.3% | 0.041 ± 0.002 | +8.2% | |
C | 0.041 ± 0.002 | 0.037 ± 0.003 ** | −11.9% * | 0.031 ± 0.002 *** | −23.8% *** | 0.039 ± 0.002 | 0.039 ± 0.002 | +10.3% | 0.041 ± 0.003 | +8.2% |