Table 5.

Associations between susceptibility and mental health symptoms in brain regions. Internalizing and Externalizing subscales were only assessed in brain regions with a significant main effect of susceptibility or a group–susceptibility interaction for Internalizing or Externalizing composite scores.

	Brain Region	Main Effect of Diagnostic Group		Main Effect of Susceptibility		Group–Susceptibility Interaction 1
		F	p	F	p	F	p
Internalizing Problems composite score	Caudate	1.66	0.203	0.213	0.646
	Putamen	1.87	0.177	0.048	0.828
	Pallidum	1.73	0.194	3.28	0.076
	Thalamus	1.81	0.185	0.091	0.764	6.16	0.016 *
	Amygdala	2.54	0.117	4.17	0.046 *
	Hippocampus	2.39	0.128	0.598	0.443
	Nucleus accumbens	3.21	0.079	7.02	0.011 *
Anxiety subscale	Thalamus	0.024	0.879	0.043	0.837	9.31	0.004 *
	Amygdala	.000215	0.988	5.01	0.029 *
	Nucleus accumbens	0.060	0.808	12.46	<0.001 **
Depression subscale	Thalamus	2.24	0.140	1.10	0.300	4.04	0.049 *
	Nucleus accumbens	4.29	0.043 *	5.45	0.023 *
Somatization subscale	Amygdala	4.54	0.038 *	1.52	0.222	4.12	0.047 *
Externalizing Problems composite score	Caudate	13.5	<0.001 **	0.911	0.344
	Putamen	16.1	<0.001 **	0.432	0.514	4.50	0.039 *
	Pallidum	14.6	<0.001 **	0.225	0.637
	Thalamus	12.2	<0.001 **	2.64	0.110
	Amygdala	14.4	<0.001 **	0.471	0.495
	Hippocampus	14.2	<0.001 **	0.061	0.806
	Nucleus accumbens	14.4	<0.001 **	0.014	0.907
Aggression subscale	Putamen	14.8	<0.001 **	0.332	0.567
Conduct subscale	Putamen	12.0	0.001 *	3.57	0.062
Hyperactivity subscale	Putamen	20.2	<0.001 **	0.883	0.352

¹ When the group–susceptibility interaction was not significant, it was removed from the final model, * p < 0.05, ** p < 0.001.