(A) Immunofluorescence micrographs of WT, heterozygous, and Selenof KO MEFs expressing adenoviral ts045-VSVG-EGFP and a Golgi marker. Representative images show the overlapping area where the VSVG-EGFP is retained in the ER-to- Golgi area, 10 min after the cells were transferred from the restrictive temperature (40°C) to the permissive temperature (32°C). Scale bars: 10 mm.
(B) Quantification of VSVG fluorescence retained in the ER-to-Golgi area. Three cell lines per each genotype and more than 10 cells per each field were evaluated. Immunofluorescence microscopy images were analyzed by ImageJ. *p < 0.05; **p < 0.01.