Table.
Vaccinations in Patients With Inflammatory Bowel Disease (IBD)a
| Vaccination | Live or inactivated | Patient population | Comment(s) |
|---|---|---|---|
| HepatitisA | Inactivated | All patients with IBD | |
| Hepatitis B | Inactivated | All patients with IBD | |
| Influenza | Inactivated | All patients with IBD | An exception is the live attenuated intranasal vaccine, which is contraindicated in immunocompromised patients |
| Pneumonia | Inactivated | All patients with IBD | Vaccination includes pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine; timing of administration per national guidelines |
| Tetanus, diphtheria, pertussis | Inactivated | All patients with IBD | |
| Special considerations | |||
| Meningitis | Inactivated | Adolescents (per national guidelines) | |
| Human papillomavirus | Inactivated | Adolescents and young adults (per national guidelines) | |
| Herpes zoster | Inactivated | Adults older than 50 y (per national guidelines) | An exception is the live vaccine, which is contraindicated in immunocompromised patients |
| Live vaccines (contraindicated in immunocompromised patients) | |||
| Influenza (intranasal) | Live | Use injectable inactivated influenza vaccine | |
| Shingles | Live | Use the recombinant inactivated vaccine | |
| Measles, mumps, rubella | Live | ||
| Rotavirus | Live | Delay until 6 mo of age if mother is receiving biologic therapy for Crohn disease | |
| Varicella | Live | ||
| Yellow fever | Live | ||
| Smallpox | Live | ||
| Oral typhoid | Live | Use injectable inactivated typhoid vaccine | |
| Bacille Calmette-Guérin | Live | ||
| Adenovirus | Live | ||
| Oral cholera | Live | ||
a
Adapted from Farraye FA, Melmed GY, Lichtenstein GR, Kane SV. ACG clinical guideline: preventive care in inflammatory bowel disease. Am J Gastroenterol. 2017;112(2):241–258. doi:10.1038/ajg.2016.537.