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. 2022 May 31;61(1):87. doi: 10.3892/ijo.2022.5377

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Knockdown of CDCA5 promotes apoptosis and impairs the inflammatory response in ccRCC cells. (A) Flow cytometric analysis after CDCA5 knockdown and subsequent staining with Annexin V and PI in the 786-O and SN12-PM6 ccRCC cell lines. (B) Expression of proteins involved in cell apoptosis, cell cycle and inflammation signaling in 786-O and SN12-PM6 cells transfected with shCDCA5 lentivirus. Data are presented as the mean ± standard deviation. ^*P<0.05, ^**P<0.01 and ^***P<0.001 vs. negative control. CDCA5, cell division cycle-associated 5; ccRCC, clear cell renal cell carcinoma; NC, negative control.