Figure 1.

Schematic representation of the study in the rheumatoid arthritis mouse model. After the induction of the pathology (collagen-induced arthritis (CIA) model), the animals were randomized into three groups, one with a placebo and the others with the administration of 20µl (NES20) or 40 µl (NES40) of neutral electrolyzed saline, all of them daily. An additional group remained without disease induction (healthy) or treatment. After 30 days of treatment and follow-up, the animals were sacrificed for histopathological analysis of their joint disease. Blood samples were also taken for IL-6 analysis.