Fig. 3.

Histology of cerebral amyloidoma. (A) Hematoxylin and Eosin (H&E) staining shows large deposits of amorphous eosinophilic material surrounded by glial tissue. No plasma cells or inflammatory cells were identified. (B) H&E staining showing focal area of bone metaplasia (arrow) associated with amyloid deposits around vessels and in surrounding brain parenchyma (C) Congo red staining highlights in orange-red the amorphous material. (D) Congo red staining under polarized light shows apple green birefringence.