Table 4.
The incidence, severity and comparison of symptoms at 3 time points (n = 197).
| Symptom | Time #1 |
Time #2 |
Time #3 |
Z | Significant | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| With symptoma |
Median (Q1, Q3) | With symptoma |
Median (Q1, Q3) | With symptoma |
Median (Q1, Q3) | ||||||
| n | % | n | % | n | % | ||||||
| Pain | 150 | 76.1 | 2 (1, 3) | 153 | 77.7 | 2 (1, 4) | 71 | 36.0∗# | 0 (0, 2)∗# | 89.913 | <0.001 |
| Fatigue (tiredness) | 93 | 47.2 | 0 (0, 2) | 150 | 76.1∗ | 2 (1, 3.5)∗ | 125 | 63.5∗# | 1 (0, 2)# | 45.640 | <0.001 |
| Nausea | 32 | 16.2 | 0 (0, 0) | 45 | 22.8 | 0 (0, 0) | 25 | 12.7# | 0 (0, 0)# | 7.812 | 0.020 |
| Disturbed sleep | 92 | 46.7 | 0 (0, 3) | 164 | 83.2∗ | 4 (2, 6)∗ | 96 | 48.7# | 0 (0, 2)# | 111.590 | <0.001 |
| Feeling of being distressed | 96 | 48.7 | 0 (0, 2) | 158 | 80.2∗ | 2 (1, 3)∗ | 153 | 77.7∗ | 2 (1, 3)∗# | 36.057 | <0.001 |
| Shortness of breath | 31 | 15.7 | 0 (0, 0) | 46 | 23.4 | 0 (0, 0) | 29 | 14.7# | 0 (0, 0) | 6.995 | 0.030 |
| Problem with remembering things | 65 | 33.0 | 0 (0,1.5) | 59 | 29.9 | 0 (0, 1) | 78 | 39.6# | 0 (0, 2) | 3.965 | 0.138 |
| Lack of appetite | 67 | 34.0 | 0 (0,1) | 64 | 32.5 | 0 (0, 1) | 51 | 25.9 | 0 (0, 1) | 3.599 | 0.165 |
| Feeling drowsy (sleepy) | 86 | 43.7 | 0 (0,2) | 151 | 76.6∗ | 3 (1, 4)∗ | 123 | 62.4∗# | 1 (0, 2)# | 59.174 | <0.001 |
| Dry mouth | 97 | 49.2 | 0 (0, 2.5) | 161 | 81.7∗ | 4 (1, 5)∗ | 139 | 70.6∗# | 1 (0, 3)∗# | 76.159 | <0.001 |
| Feeling sad | 75 | 38.1 | 0 (0, 2) | 108 | 54.8∗ | 1 (0, 2)∗ | 69 | 35.0# | 0 (0, 1)# | 17.033 | <0.001 |
| Vomiting | 17 | 8.6 | 0 (0, 0) | 33 | 16.8∗ | 0 (0, 0)∗ | 23 | 11.7 | 0 (0, 0) | 6.606 | 0.037 |
| Numbness/tingling | 67 | 34.0 | 0 (0, 2) | 136 | 69.0∗ | 2 (0, 4)∗ | 172 | 87.3∗# | 3 (1, 4)∗ | 111.5867 | <0.001 |
| Problems with mucus | 114 | 56.9 | 1 (0, 3) | 173 | 87.8∗ | 4 (2, 6)∗ | 144 | 73.1∗# | 2 (0, 3)∗# | 87.676 | <0.001 |
| Difficulty swallowing/chewing | 126 | 64.0 | 2 (0, 5) | 188 | 95.4∗ | 8 (5, 9)∗ | 172 | 87.3∗# | 3 (2, 5)∗# | 167.830 | <0.001 |
| Choking/coughing (aspiration) | 54 | 27.4 | 0 (0, 1) | 39 | 19.8 | 0 (0, 0) | 50 | 25.4 | 0 (0, 1) | 1.974 | 0.373 |
| Difficulty with voice/speech | 82 | 41.6 | 0 (0, 2) | 186 | 94.4∗ | 5 (3, 8)∗ | 172 | 87.3∗# | 2 (1, 4)∗# | 205.139 | <0.001 |
| Skin pain/burning/rash | 41 | 20.8 | 0 (0, 0) | 50 | 25.4 | 0 (0, 1) | 48 | 24.4 | 0 (0, 0) | 1.442 | 0.486 |
| Constipation | 48 | 24.4 | 0 (0, 0) | 46 | 23.4 | 0 (0, 0) | 60 | 30.5 | 0 (0, 1) | 2.166 | 0.339 |
| Problem with tasting food | 45 | 22.8 | 0 (0, 0) | 51 | 25.9 | 0 (0, 1) | 74 | 37.6∗# | 0 (0, 2)∗ | 11.319 | 0.003 |
| Mouth/throat sores | 122 | 61.9 | 1 (0, 3) | 139 | 70.6 | 2 (0, 3) | 80 | 40.6∗# | 0 (0, 1)∗# | 51.938 | <0.001 |
| Problem with teeth/gum | 116 | 58.9 | 1 (0, 3.5) | 120 | 60.9 | 2 (0, 5) | 127 | 64.5 | 1 (0, 4) | 2.532 | 0.282 |
| MDASI [Median (Q1, Q3)] | 20 (9, 40) | 43 (31.5, 60.0)∗ | 24 (16, 33.5)# | 109.494 | <0.001 | ||||||
∗P < 0.05 compared with Time #1.
#P < 0.05 compared with Time #2.
a
The percentage of patients who reported any level (1–10) of the symptom surveyed.