Table 1.
Characteristics of the study cohort
| Gonadotropin cycles (2007–2017) | ||||||||
|---|---|---|---|---|---|---|---|---|
| REC | EXT | CBD | Total | |||||
| N = 45,554 (50.5%) | N = 24,509 (27.1%) | N = 20,229 (22.4%) | N = 90,292 | |||||
| Age of woman | % | % | % | % | ||||
| 18–24 | 303 | 0.7 | 136 | 0.6 | 50 | 0.2 | 489 | 0.5 |
| 25–29 | 2731 | 6.0 | 1146 | 4.7 | 750 | 3.7 | 4627 | 5.1 |
| 30–34 | 10,608 | 23.3 | 5079 | 20.7 | 3654 | 18.1 | 19,341 | 21.4 |
| 35–39 | 17,825 | 39.1 | 9817 | 40.1 | 8115 | 40.1 | 35,757 | 39.6 |
| 40–45 | 14,087 | 30.9 | 8331 | 34.0 | 7660 | 37.9 | 30,078 | 33.3 |
| Measures of overall health status (6 months prior the index date) | ||||||||
| Number of co-medication (distinct ATC at 4 level) | ||||||||
| 0 | 6954 | 15.3 | 4166 | 17.0 | 2155 | 10.7 | 13,275 | 14.7 |
| 1–3 | 17,339 | 38.1 | 9799 | 40.0 | 6414 | 31.7 | 33,552 | 37.2 |
| 4–7 | 12,737 | 28.0 | 6507 | 26.5 | 5844 | 28.9 | 25,088 | 27.8 |
| 8 + | 8524 | 18.7 | 4037 | 16.5 | 5816 | 28.8 | 18,377 | 20.4 |
| Prior hospitalisation | ||||||||
| Yes | 7141 | 15.7 | 3406 | 13.9 | 2978 | 14.7 | 13,525 | 15.0 |
| Prior emergency room visits | ||||||||
| Yes | 4524 | 9.9 | 2392 | 9.8 | 2059 | 10.2 | 8975 | 9.9 |
| Number of prior outpatient visits | ||||||||
| 0 | 22,158 | 48.6 | 9232 | 37.7 | 9609 | 47.5 | 40,999 | 45.4 |
| 1–2 | 12,006 | 26.4 | 6457 | 26.3 | 5595 | 27.7 | 24,058 | 26.6 |
| 3–8 | 9719 | 21.3 | 7229 | 29.5 | 4273 | 21.1 | 21,221 | 23.5 |
| 9 + | 1671 | 3.7 | 1591 | 6.5 | 752 | 3.7 | 4014 | 4.4 |
| Comorbidities | ||||||||
| Alcohol abuse | 19 | 0.0 | 3 | 0.0 | 9 | 0.0 | 31 | 0.0 |
| Asthma | 51 | 0.1 | 29 | 0.1 | 23 | 0.1 | 103 | 0.1 |
| Cardiac valvular disease | 19 | 0.0 | 9 | 0.0 | 5 | 0.0 | 33 | 0.0 |
| Gestational diabetes mellitus | 244 | 0.5 | 114 | 0.5 | 104 | 0.5 | 462 | 0.5 |
| Preexisting diabetes mellitus | 54 | 0.1 | 34 | 0.1 | 26 | 0.1 | 114 | 0.1 |
| Drug abuse | 11 | 0.0 | 5 | 0.0 | 5 | 0.0 | 21 | 0.0 |
| Severe pre-eclampsia/eclampsia | 39 | 0.1 | 20 | 0.1 | 14 | 0.1 | 73 | 0.1 |
| Mild or unspecified pre-eclampsia | 83 | 0.2 | 28 | 0.1 | 42 | 0.2 | 153 | 0.2 |
| Endometriosis | 1243 | 2.7 | 566 | 2.3 | 541 | 2.7 | 2350 | 2.6 |
| Polycystic ovary syndrome | 52 | 0.1 | 35 | 0.1 | 15 | 0.1 | 102 | 0.1 |
| Sickle cell disease | 20 | 0.0 | 32 | 0.1 | 13 | 0.1 | 65 | 0.1 |
| Cystic fibrosis | 5 | 0.0 | 5 | 0.0 | 2 | 0.0 | 12 | 0.0 |
| HIV | 15 | 0.0 | 16 | 0.1 | 11 | 0.1 | 42 | 0.0 |
| Female infertility | 8309 | 18.2 | 3555 | 14.5 | 3432 | 17.0 | 15,296 | 16.9 |
| Chronic ischemic heart disease | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
| Pulmonary hypertension | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 |
| Preexisting hypertension | 204 | 0.4 | 109 | 0.4 | 110 | 0.5 | 423 | 0.5 |
| Gestational hypertension | 166 | 0.4 | 72 | 0.3 | 89 | 0.4 | 327 | 0.4 |
| Chronic ischemic heart disease | 8 | 0.0 | 7 | 0.0 | 6 | 0.0 | 21 | 0.0 |
| Systematic lupus erythematosus | 11 | 0.0 | 4 | 0.0 | 4 | 0.0 | 19 | 0.0 |
| Congenital heart disease | 22 | 0.0 | 13 | 0.1 | 12 | 0.1 | 47 | 0.1 |
| Chronic renal disease | 37 | 0.1 | 12 | 0.0 | 14 | 0.1 | 63 | 0.1 |
| Multiple gestation | 1019 | 2.2 | 420 | 1.7 | 450 | 2.2 | 1889 | 2.1 |
| Obesity | 100 | 0.2 | 49 | 0.2 | 33 | 0.2 | 182 | 0.2 |
| Placenta previa | 141 | 0.3 | 68 | 0.3 | 65 | 0.3 | 274 | 0.3 |
| Cervical polyp | 2934 | 6.4 | 1640 | 6.7 | 1417 | 7.0 | 5991 | 6.6 |
| Previous caesarean delivery | 40 | 0.1 | 27 | 0.1 | 14 | 0.1 | 81 | 0.1 |
| Tobacco use | 2 | 0.0 | 1 | 0.0 | 0 | 0.0 | 3 | 0.0 |
| Tumours | 167 | 0.4 | 84 | 0.3 | 67 | 0.3 | 318 | 0.4 |