Table 2.
Clinical and Surgical Data of 192 Patients, with “Soft” Pancreas and Small Diameter of the Main Duct, Who Underwent Pancreatico-duodenectomy with Conventional Reconstruction (96 pts) or Isolated- Loop Reconstruction (96 pts) after Propensity Score Matching
| Data | Conventional Reconstruction (n = 96) | Isolated-Loop Reconstruction (n = 96) | p |
|---|---|---|---|
| Patient factors | |||
| Age, mean (SD), yr | 62.07 (11.08) | 63.44 (10.78) | 0.620 |
| Sex, n (%) | |||
| Male | 56 (58.3) | 50 (52.1) | 0.384 |
| Female | 40 (41.7) | 46 (47.9) | |
| BMI, mean (SD) | 25.59 (± 2.09) | 25.82 (± 2.39) | 0.254 |
| BMI ≥ 25 n (%) | 56 (58) | 57 (59) | 0.883 |
| Site of tumor | |||
| Pancreas n (%) | 37 (38.5) | 38 (39.6) | 0.882 |
| Other tumors, n(%) | 59 (61.5) | 58 (60.4) | |
| Common bile duct, n (%) | 24 (25.0) | 25 (26.0) | 0.868 |
| Ampulla, n (%) | 29 (30.2) | 30 (31.3) | 0.876 |
| Duodenum, n (%) | 6 (6.3) | 3 (3.1) | 0.306 |
| Preoperative biliary drainage | 65 (67.7) | 66 (68.8) | 0.877 |
| Wirsung diameter, mean (SD), mm | 1.39 (0.49) | 1.39 (0.49) | 1.000 |
| Surgical factors | |||
| Whipple procedure, n (%) | 51(53.1) | 50 (52) | 0.885 |
| Pylorus preserving | 45(46.9) | 46(48) | |
| Type of anastomosis | |||
| Duct-to mucosa | 78 (81.2) | 72 (75) | 0.295 |
| Stump invagination | 18 (18.8) | 24 (25.0) | |
| Duration of surgery, mean (SD), minutes | 505.41 (62.03) | 529.54 (58.43) | 0.657 |
| Intraoperative blood loss, n (%) | |||
| < 400 ml | 82 (85.4) | 82 (85.4) | |
| 400 – 700 ml | 13 (13.5) | 13 (13.5) | 1.000 |
| 700 – 1000 ml | 1 (1.0) | 1 (1.0) | |
| Postoperative outcomes | |||
| Postoperative stay, mean (SD), days | 21.54 (12.26) | 15.14 (4.56) | 0.001 |
| 90-day mortality, n (%) | 2 (2.1) | 2 (2.1) | 1.000 |
| Postoperative complications, n (%) | |||
| POPF | 66 (68.7) | 54 (56.2) | 0.074 |
| Biochemical leak | 25 (26.0) | 29 (30.2) | 0.521 |
| Clinically relevant POPF | 41 (42.7) | 25 (26.0) | 0.015 |
| Delayed gastric emptying | 44(45.8) | 40 (41.7) | 0.561 |
| Postoperative pancreatic hemorrhage | 4 (4.2) | 7 (7.3) | 0.352 |
| Re-laparotomy | 14 (14.6) | 13 (13.5) | 0.836 |
| Interventional radiology, (n%) | 37 (38.5) | 20 (20.8) | 0.007 |
Abbreviations: SD, standard deviation, POPF, postoperative pancreatic fistula