Fig. 4.

Sex-specific Quartiles of T/E2 Ratio and Platelet Activation. Platelet aggregation (A) and TxB2 biosynthesis (B) were evaluated in platelets from healthy subjects incubated with different T/E2 ratio, 11.63 or 22.19 corresponding to the lowest and highest quartiles of the T/E2 ratio for male and 0.897 or 2.71 corresponding to the lowest and highest quartiles of the T/E2 ratio for female, before stimulation with a subthreshold concentration of collagen (STC, 0.25 μg/ml). Data shown are means ± SD and were compared with Mann–Whitney U (for the comparisons between two groups) and Kruskal–Wallis H (for the comparisons between three or more group). *p < 0.05; **p < 0.01; ***p < 0.001