Table 1.
Baseline characteristics stratified by sex
| Variables | Women (n = 133) |
Men (n = 301) |
p value |
|---|---|---|---|
| Age (years) mean ± SD | 69.8 ± 11.5 | 65.4 ± 10.7 | < 0.001 |
| BMI (kg/m2) mean ± SD | 26.3 ± 5.0 | 27.5 ± 4.0 | 0.009 |
| Family Hx CVD | 72 (55.8) | 191 (64.7) | 0.08 |
| Smoking | 25 (19.1) | 86 (28.9) | 0.031 |
| Hypertension | 97 (73.5) | 246 (81.7) | 0.05 |
| Heart Failure | 11 (8.3) | 45 (14.9) | 0.59 |
| Dyslipidemia | 61 (46.2) | 162 (54.2) | 0.12 |
| Type 2 Diabetes | 28 (21.2) | 90 (29.9) | 0.061 |
| Known IHD | 27 (20.4) | 127 (42.2) | < 0.001 |
| Prior AMI | 18 (13.5) | 92 (30.6) | < 0.001 |
| Vascular Disease# | 27 (20.4) | 82 (27.2) | 0.13 |
| Prior Stroke/TIA | 18 (13.6) | 28 (9.3) | 0.17 |
| Dementia | 1 (0.8) | 2 (0.7) | 0.91 |
| End Stage Chronic Kidney/Dialysis | 0 (0) | 6 (1.9) | 0.10 |
| COPD | 15 (11.4) | 32 (10.6) | 0.82 |
| Statins at admission | 50 (37.9) | 148 (49.2) | 0.029 |
| Anti-platelets at admission | < 0.001 | ||
| Single | 49 (37.1) | 147 (48.8) | |
| DAPT | 8 (6.1) | 46 (15.3) | |
| Acute Coronary Syndrome Yes | 78 (58.6) | 149 (49.5) | 0.07 |
| Type of CAD | < 0.001 | ||
| Obstructive CAD | 83 (62.4) | 236 (78.4) | |
| Non-obstructive CAD | 50 (37.6) | 65 (21.6) | |
| Creatinine (mg/dl) mean ± SD | 0.85 ± 0.30 | 1.07 ± 0.54 | < 0.001 |
| Platelet Count (× 103) mean ± SD | 241.6 ± 71.5 | 209.8 ± 58.0 | < 0.001 |
| Hemoglobin (g/dL) media ± SD | 13.1 ± 1.5 | 14.4 ± 1.6 | < 0.001 |
| Estradiol (pg/mL) median [IQR] | 10.0 [9.5–17.0] | 24.0 [16.0–31.0] | < 0.001 |
| Testosterone (nmol/L) median [IQR] | 0.8 [0.5–1.2] | 14.1 [9.9–17.6] | < 0.001 |
| T/E2 Ratio median [IQR] | 1.8 [0.9–2.71] | 15.8 [11.5–22.0] | < 0.001 |
| Thromboxane (pg/ml), median [IQR]* | 152.0 [116.0–187.0] | 147.3 [96.0–220.6] | 0.40 |
| NO (uM) median [IQR]* | 21.5 [12.5–30.2] | 17.9 [8.1–38.8] | 0.39 |
AMI Acute Myocardial Infarction, BMI body mass index, CAD coronary artery disease, COPD chronic obstructive pulmonary disease, DAPT dual-antiplatelet therapy, Hx history, PAD TIA transient ischemic attack
*Data available on 428 patients
#Peripheral artery disease and/or Carotid Stenosis