Fig. 2. Genetic determinants of telomere length.
a Heritability estimation using a GREML model on the genotyped SNP data, from which a kinship matrix was estimated using GCTA40. The kinship matrix was used in a mixed model to estimate the variation explained by the genetic random effect. Units of heritability are represented as h2. b Manhattan plot of genome-wide associations to telomere length from all cell types. Blue line indicates a suggestive significance threshold of p = 1 × 10−5. Red line indicates the standard genome-wide threshold of p = 5 × 10−8. The novel association with TERT, rs33961405 (5:1277577:G:A GRCh37), is labelled with its corresponding rsid. c Correlation of the Polygenic Risk Score (PRS) of telomere length15 and telomere length of different cell types. Each square represents the estimated effect of the PRS in the cell type. Bars indicate 95% confidence interval.