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. 2022 May 27;13:904288. doi: 10.3389/fimmu.2022.904288

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Copyright © 2022 Wu, Peng, Li, Zhang, Liu, Lu, Peng, Zhou, Fei, Zeng, Zhao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the clustering and annotation of the sc-RNA sequencing data for IgG4-RD. (A) UMAP representation of 47,219 single cells from HCs (n = 3) and IgG4-RD (n = 4), showing the formation of 21 clusters. (B) Canonical cell markers used to label major cell types represented in the UMAP plot. The legend is labeled in log scale. (C) Bar plot showing cluster abundance of major cell types across all samples. (D) Bubble heatmap showing the selected markers annotating specific cell types. The size of the dot indicates the fraction of expressing cells, colored according to z-score–normalized expression levels.