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. 2022 May 27;13:904288. doi: 10.3389/fimmu.2022.904288

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Copyright © 2022 Wu, Peng, Li, Zhang, Liu, Lu, Peng, Zhou, Fei, Zeng, Zhao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The heterogeneity and transcriptional features of B-cell subsets in IgG4-RD. (A) UMAP representation of 2,449 B cells, showing the formation of five clusters. (B) Violin plots showing expression distribution of canonical cell markers. (C) Bar plot showing cluster abundance of each B-cell type across all samples. (D) Percentages of four types of B-cell between HCs and patients with IgG4-RD. The y-axis shows the average percentage of B-cell subtypes in total B cells. Error bars are shown in mean ± SEM. Student t-test was used for the analysis, and P < 0.05 is considered as a significant difference, ns stands for nonsignificant. (E) Volcano plot showing the DEGs of B-cell subtypes between HCs and patients with IgG4-RD. (F) GSEA results showing the significantly enriched pathways in Memory-unswitched (Mem-unsw) B cells and Plasma B cells of patients with IgG4-RD.