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. 2022 May 27;13:904288. doi: 10.3389/fimmu.2022.904288

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Copyright © 2022 Wu, Peng, Li, Zhang, Liu, Lu, Peng, Zhou, Fei, Zeng, Zhao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The heterogeneity and transcriptional features of myeloid cells in IgG4-RD. (A) UMAP representation of 6324 myeloid cells, showing the formation of 8 clusters. (B) Violin plots showing expression distribution of canonical cell markers. (C) Bar plot showing cluster abundance of each myeloid cell type across all samples. (D) Percentages of DC and CD14⁺ Mono between HCs and IgG4-RD. The y-axis shows the average percentage. Error bars are shown in mean ± SEM. Student t-test was used for the analysis, and P < 0.05 is considered a significant difference. (E) Volcano plot showing the DEGs of myeloid cell subtypes between HCs and patients with IgG4-RD. Data are expressed as mean ± SD.