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. 2022 May 27;13:904288. doi: 10.3389/fimmu.2022.904288

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Copyright © 2022 Wu, Peng, Li, Zhang, Liu, Lu, Peng, Zhou, Fei, Zeng, Zhao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional analysis of myeloid cells in IgG4-RD. (A) Violin plots showing expression of EGR1 and CD36 in different CD14⁺ mono subtypes. (B, C) The comparison of EGR1 and CD36 expressions in purified CD14⁺ monocytes from HCs and patients with IgG4-RD. (D) GO analysis showing the biological process enriched in different CD14⁺ monocytes of patients with IgG4-RD. (E) CD14⁺ monocytes purified from PBMCs of HCs and patients with IgG4-RD and cultured for 12 h in vitro. The TNF-α in the supernatant was measured using ELISA. Data are expressed as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.