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. 2022 May 27;10:824938. doi: 10.3389/fcell.2022.824938

TABLE 1.

Univariate and multivariate Cox regression analyses of OS/DFS and clinicopathological features in HCC patients.

Overall survival Univariate analysis Multivariate analysis
HR (95%CI) p-value HR (95%CI) p-value
Age (≥60 vs. < 60) 1.27 (0.9–1.8) 0.181
Gender (male vs. female) 1.21 (0.85–1.73) 0.282
MELK (high vs. low) 1.66 (1.17–2.37) 0.005 1.54 (1.05–2.24) 0.026*
T stage (T3–T4 vs. T1–T2) 2.5 (1.76–3.56) <0.001 2.3 (1.58–3.35) <0.001*
Pathologic stage (III–IV vs. I–II) 2.41 (1.66–3.49) <0.001 1.21 (0.17–8.82) 0.849
Histologic grade (III–IV vs. I–II) 1.14 (0.8–1.63) 0.47
Child–Pugh grade (B–C vs. A) 1.62 (0.8–3.28) 0.183
Vascular invasion (positive vs. negative) 1.32 (0.87–2) 0.188
Family history (yes vs. no) 1.16 (0.81–1.68) 0.415
Disease-free survival Univariate analysis Multivariate analysis
HR (95%CI) p-value HR (95%CI) p-value
Age (≥60 vs. < 60) 1.04 (0.77–1.4) 0.817
Gender (male vs. female)) 0.97 (0.7–1.33) 0.828
MELK (high vs. low) 1.53 (1.13–2.08) 0.006 1.51 (1.05–2.16) 0.026*
T stage (T3–T4 vs. T1–T2) 2.15 (1.55–2.97) <0.001 0.33 (0.08–1.4) 0.131
Pathologic stage (III–IV vs. I–II) 2.18 (1.56–3.05) <0.001 5.82 (1.4–24.16) 0.015*
Histologic grade (III–IV vs. I–II) 1.19 (0.87–1.62) 0.273
Child–Pugh grade (B-C vs. A) 1.42 (0.78–2.6) 0.253
Vascular invasion (positive vs. negative) 1.64 (1.16–2.32) 0.005 1.33 (0.91–1.93) 0.141
Family history (yes vs. no) 1 (0.72–1.39) 0.991