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. 2022 Jun 9;13:3191. doi: 10.1038/s41467-022-30928-x

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Box plot showing the gene expression levels in human GV oocytes of different ages. n = 3 biologically independent samples were included in each group. The box indicates the upper and lower quantiles, the thick line in the box indicates the median and whiskers indicates 2.5th and 97.5th percentiles.. P-values by a two-tailed Student’s t-test are indicated. b Scatter plots of RNA-seq data illustrating transcriptional changes in human GV oocytes of different ages. Transcripts decreased or increased by more than 2-fold or 5-fold compared with oocytes of women younger than 30 years old were highlighted with different colors. c Venn diagram showing the overlap of transcripts that decreased more than 5 fold in GV oocytes from women of different ages, compared with oocytes of women younger than 30 years old. d Gene ontology analysis of transcripts significantly downregulated in aged GV oocytes. P-values by a two-tailed Student’s t-test are indicated. e Heat maps showing the level changes in representative transcripts in the indicated functional categories.