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. 2022 Jun 9;13:3191. doi: 10.1038/s41467-022-30928-x

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© The Author(s) 2022, corrected publication 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Scatter plots of RNA-seq data illustrating the transcriptional changes in human MII oocytes of different ages. Transcripts that decreased or increased by more than 2-fold or 5-fold compared with oocytes of women younger than 30 years old are highlighted with different colors. b Box plot showing gene expression levels in human MII oocytes of different ages. n = 3 biologically independent samples were included in each group. The box indicates the upper and lower quantiles, the thick line in the box indicates the median and whiskers indicates 2.5th and 97.5th percentiles.. P-values by a two-tailed Student’s t-test are indicated. c Box plot showing fold changes in mRNA levels in MII versus GV oocytes from women of different ages. n = 3 biologically independent samples were included in each group. The box indicates the upper and lower quantiles, the thick line in the box indicates the median and whiskers indicates 2.5th and 97.5th percentiles. P-values by a two-tailed Student’s t-test are indicated. d Venn diagram showing the overlap of M-decay transcripts (decreased 5 fold from GV to MII stage) in oocytes from women younger and older than 35 years. e Degradation patterns of human maternal transcripts during the GV-MII transition in oocytes derived from women aged ≤ and >35 years. Each light blue line represents the expression levels of one gene, and the middle red and green lines represent the median expression levels of the group. Transcripts with FPKM > 1 at the GV stage were selected and analyzed.