Table 3.

The alteration observed in the molecular species of 20 most discriminating (according to One-way ANOVA) PL species from PC, LPC, PE and SM class in the plasma of healthy subjects (Control) and TBE patients (TBE) and TBE patients with co-infections (TBE + LD/HGA); mean difference was significant at the 0.05 level (p < 0.0001****; p < 0.001***; n.s.–not significant; the up arrows represent up-regulation and down arrows represent down-regulation.

PL class	PL specie	PL molecular specie	Log2 (fold-change)
			TBE vs Control	p-value	TBE + LD/HGA vs Control	p-value	TBE + LD/HGA vs TBE	p-value
PC	PC(38:3)	PC(18:1/18:2)	2.66 ↑	****	3.18 ↑	****	–	ns
PC	PC(40:6)	PC(18:0/22:6)	2.71 ↑	****	3.16 ↑	****	–	ns
PC	PC(40:5)	PC(18:0/22:5)	2.70 ↑	****	2.99 ↑	****	–	ns
PC	PC(42:5)	PC(20:0/22:5)	2.75 ↑	****	2.94 ↑	****	–	ns
SM	SM(d36:1)	SM(d18:1/18:0)	1.59 ↓	****	1.55 ↑	****	3.14 ↑	****
SM	SM(d34:1)	SM(d18:1/16:0)	2.20 ↓	****	–	ns	2.85 ↑	****
PC	PC(38:6)	PC(16:0/22:6)	2.99 ↑	****	3.65 ↑	****	–	ns
SM	SM(d42:2)	SM(d18:1/24:1)	1.71 ↓	****	1.32 ↑	****	3.03 ↑	****
PC	PC(38:5)	PC(18:1/20:4)	2.40 ↑	****	3.02 ↑	****	–	ns
SM	SM(d42:3)	SM(d18:1/24:2)	1.54 ↓	****	1.43 ↑	****	2.96 ↑	****
LPC	LPC(16:0)	LPC(16:0)	2.92 ↑	****	2.41 ↑	****	–	ns
SM	SM(d40:2)	SM(d18:1/22:1)	2.06 ↓	****	1.07 ↑	***	3.13 ↑	****
PC	PC(38:4)	PC(18:0/20:4)	3.10 ↑	****	3.94 ↑	****	–	ns
LPC	LPC(18:0)	LPC(18:0)	3.41 ↑	****	2.35 ↑	****	1.06 ↓	***
LPC	LPC(18:1)	LPC(18:1)	3.63 ↑	****	3.12 ↑	****	–	ns
PC	PC(36:1)	PC(16:0/20:1)	2.11 ↑	****	2.88 ↑	****	–	ns
PE	PE(38:6)	PE(16:0/22:6)	3.20 ↑	****	1.65 ↑	****	1.55 ↓	****
PC	PCp(38:4)	PC(P-18:0/20:4)	1.97 ↑	****	2.31 ↑	****	–	ns
PE	PE(38:5)	PE(16:0/22:5)	2.16 ↑	****	–	ns	2.01 ↓	****
PE	PE(38:4)	PE(16:0/22:4)	1.99 ↑	****	–	ns	1.99 ↓	****