Fig. 3.

Developmental mLV dysfunction does not exacerbate anxiety and learning-memory deficits in the early chronic phase post-TBI. (A) Open field task was used to evaluate anxiety in CCI and SHAM control mice. No genotype or injury differences were visible in the time spent in the center of the open field. (B–F) Learning and memory were assessed using the Morris swim task (‘water maze’). The different parameters analyzed show a significant injury effect, but no differences between TG and WT mice. (B) Swimming speed; (C) Escape latency; (D) Average distance to the platform; (E) Wall-hugging (thigmotaxis); (F) Time spent in the platform zone on the probe trial (day 5). (G) No significant differences were observed in the passive avoidance task related to TBI induction or developmental deficits in the mLVs. Data analyses: linear mixed-effect model (lme) with Sidak correction. OF: open field, MWM: Morris water maze, PaAvo: passive avoidance. P-values are reported for the genotype effect analysis.