Fig. 4.

Effect of developmental mLV dysfunction on TBI-related chronic microglia activation. (A) Representative photomicrographs (green; original magnification: × 10; scale bar = 1000 μm) showing Iba1-positive cells in cortical and subcortical areas of sham and CCI mice, 2 months post-TBI induction. Inserts in each panel show magnified microglial cells in representative areas of interest (original magnification, × 25; scale bar = 20 μm). (B, C) Quantitative analysis of number of Iba1-positive cells in the hippocampi (B) and in the auditory cortex (C) of WT-CCI and TG-CCI mice. (D) Quantitative analysis of percentage of ramified and activated microglia in the hippocampi of WT-CCI and TG-CCI mice. (E) Quantitative analysis of percentage of ramified and activated microglia in the auditory cortex of WT-CCI and TG-CCI mice. Data analyses: general linear model (GLM) with Sidak correction. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)