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. 2022 Jun 9;6:36. doi: 10.1038/s41698-022-00276-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Tumors with deleterious alterations in BRAC1/2 (H1a), in other HHR genes (H1b), VUS in BRCA1/2 (H2a) and in other HRR genes (H2b). b Distribution of the HRDsum score and percentage of cases classified as HRD-positive by HRDsum (cutpoint: 42) and by SBS3 (cutpoint: 0). HRDsum was calculated starting from genotyping data (SNP arrays). c Percentage of HRD-positive (HRDsum ≥ 42) tumors in the five classes H1a-H3 (grey = no cases). Significant enrichments of HRD-positive tumors compared to H3 are shown in bold face.