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. 2022 Jun 9;6:36. doi: 10.1038/s41698-022-00276-6

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Percentages of strongly and moderately hypermethylated tumors pan-cancer and in specific cancer types. Top line: number of methylated tumors of each cancer type. b Association of methylation status with HRD-positivity (HRDsum ≥ 42). All strongly hypermethylated tumors and 43% of the moderately hypermethylated tumors were HRD-positive.