Fig. 6. Blockage of the conversion of the LTP trace impairs the ocular dominance plasticity in young adult mice.
a A diagram illustrating that DSPL disrupts the direct interaction of the β2-adrenergic receptor with PSD-95. b Experiment timeline. For the MD, the contralateral eye to the recorded hemisphere was closed for 7 days before the ISI. Peptide infusion was started when the eye closed. c–f Representative visual cortical response of the mouse normal reared (c), after 7 days of MD (d), after 7 days of MD with the infusion of DSPL (e), and after 7 days of MD with the infusion of the control peptide, DAPA (f). Left and middle: each magnitude map shows the visual cortical response from the contralateral (C) or the ipsilateral (I) eye from the recorded hemisphere. Gray scale: response amplitude as the fractional change in reflection ×104. Arrows: L, lateral, R, rostral. Right: histogram of the ODI illustrated in the number of pixels (x-axis: ODI, y-axis: number of pixels). g–i Summary of the response amplitude evoked by the contralateral (g) and ipsilateral (h) eye as well as the ODI (i) of each group. Box plot: average ± s.e.m. One-way ANOVA and post hoc Holm–Sidak’s multiple comparison test, g F(3,33) = 0.578, p = 0.633; h F(3,32) = 6.267, p = 0.001; i F(3,33) = 12.31, p < 0.001; *p < 0.05, **p < 0.01, ***p < 0.001. Source data are provided as a Source Data file.