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. 2022 Jun 9;8:72. doi: 10.1038/s41523-022-00439-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Assessed by independent central review in the brain metastasis-negative population. Second-line patients were defined as those who received one line of therapy in the metastatic setting and recurred ≤12 months after (neo)adjuvant chemotherapy, prior to study enrollment. BICR blinded independent central review, HR hazard ratio, (neo)adjuvant neoadjuvant or adjuvant, PFS progression-free survival, SG sacituzumab govitecan, TPC treatment of physician’s choice.