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. 2022 Jun 9;13:3340. doi: 10.1038/s41467-022-31073-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heat map and volcano plot of differential gene expression (DESeq2, padj < 0.05) in Setd1a+/− relative to the WT siblings (DIV 30). Comparative enrichment of Gene Ontology: Biological Process (GO:BP) and Cellular Components (GO:CC) terms is shown for up (green) and down (blue) regulated genes. Also see Supplementary Fig. 12 for complete list. b Schematics summarizing the modulation of Mef2c activity by Setd1a. c Gene expression heat maps are shown for up- and down- regulated genes. Magenta-colored genes are also known targets from Mef2c ChIP-seq studies. d Bootstrap sampling (10⁶) for estimating statistical significance of overlap with Mef2c targets by chance. P-values are uncorrected probabilities as defined in the panel. All sample replicates are biological.