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. 2022 Jun 9;13:3340. doi: 10.1038/s41467-022-31073-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Barplots comparing various quantitative measures of network function of WT sibling MoNNets (blue) and Setd1a+/− MoNNets treated with DMSO(orange), ORY-1001(green) and TCP(red). All treatments were for two days. From left to right: local and global functional connections stability as measured by the correlation in edge weights of functional graph before and after the treatment; local and global coefficient of determination (r-square fit edge weights before and after treatment) quantifying the predictability of the after-treatment state; average pairwise correlation increment as measured by increase in correlation of same pair before and after, averaged over an entire MoNNet; global graph efficiency increment measures of functional graphs; activity rate per minute. Statistical significance were calculated by using one-way ANOVA and Dunnett multiple comparison test with WT sibling or Setd1a + /− group as controls (***padj < 0.001; **padj < 0.01; *padj < 0.05). Error bars represent 95% confidence interval and center are means. All samples are biological replicates. b, Representative examples of WT sibling MoNNets and Setd1a+/− MoNNets treated with DMSO, ORY-1001, and TCP. Nodes belonging to same modules are colored same. Co-classification matrix heatmap and clustering dendrograms are shown to visualize the hierarchical relationship in modules activity. The density scatter plot compares edge weight before and after treatment. PCC: Pearson’s correlation coefficient of the scatter plot; Rsq: r-square measure of fitness of linear regression fit with a straight line. Source data are provided as a Source Data file.