Table 3.
Demographic, epidemiological, clinical, and therapeutic aspects, and outcome of patients with non-wild type Sporothrix brasiliensis strains.
| Case | Sex/age (years) | Year of Sporothrix isolation | Transmission | Clinical Form | Comorbidity/Immunosuppression | nWT | Treatment | Outcome | |
|---|---|---|---|---|---|---|---|---|---|
| Antifungal | Months | ||||||||
| 1 | F/54 | 2000 | Cat scratch | LC | NA | ITR | ITR up to 400 mg/day | 9 | Loss of follow-up |
| 2 | F/63 | 2000 | Cat bite | DC | None | KET | ITR up to 400 mg/day, FLU 200 mg/day, curettage | 9 | Cure |
| 3 | M/18 | 2003 | Contact with diseased cat and soil/plants | Disseminated | Alcoholism | ITR POS KET | ITR up to 400 mg/day, AMB 8,885 mg | 37 | Cure |
| 4 | F/34 | 2004 | Cat scratch | LC | HBP and obesity | KET | ITR 100 mg/day | 6 | Cure |
| 5 | F/66 | 2005 | Contact with cat | LC | None | ITR AMB | ITR 100 mg/day, cryosurgery, curettage | 14 | Cure |
| 6 | M/60 | 2006 | Cat scratch | DC | Stroke sequelae | KET | ITR 100 mg/day, cryosurgery, curettage | 15 | Cure |
| 7 | M/68 | 2007 | Cat bite and scratch | LC | HBP | KET | TRB up to 500 mg/day, ITR up to 200 mg/day, cryosurgery, curettage | 38 | Cure |
| 8* | F/34 | 2008 | Cat bite and scratch | DC | None | ITR | TRB 250 mg/day | 4 | Cure |
| 9 | M/45 | 2012 | No history | Disseminated | HIV, alcoholism | AMB | ITR up to 200 mg/day, AMB 11,420 mg | 16 | Death |
| 10 | M/43 | 2015 | Contact with cat | Disseminated | Renal transplant | AMB | ITR 200 mg/day, AMB | 8 | Death |
| 11 | F/73 | 2016 | Cat scratch | LC and EC unifocal (bone and tendon) | DM, HBP | TRB | ITR up to 400 mg/day, TRB 250 mg/day | 34 | Cure (Amputation of 4th left finger) |
| 12 | M/29 | 2016 | Cat scratch | Disseminated | HIV | KET | ITR 200 mg/day, AMB 2,000 mg | 4 | Death |
| 13** | F/73 | 2016 | Cat scratch | DC (leg and hand) | HBP | ITR | ITR 100 mg/day | 84 | Treating |
nWT, non-wild type drug; M, male; F, female; DC, disseminated cutaneous form; LC, lymphocutaneous form; EC, extracutaneous form; DM, diabetes mellitus; HBP, high blood pressure; HIV, human immunodeficiency virus; ITR, itraconazole; TRB, terbinafine; AMB, amphotericin B; FLC, fluconazole; *Relapse 3 months later and treated with TRB 250 mg for 1 month. **Two episodes of previous cutaneous sporotrichosis 10 years before. NA, not available.