Figure 1.

Right amygdalar rsFC network in adolescents with NeuP compared to control participants. (A) Location of the right amygdala seed. (B) We observed decreased amygdalar resting-state functional connectivity (rsFC) to the right dorsolateral prefrontal cortex (dlPFC), and increased rsFC to the left angular gyrus (AG), in patients compared to healthy controls (HC), significant at cluster-corrected P_FDR < 0.025. (C) Individual participant rsFC values between the right amygdala and the dlPFC, plotted separately for male and female NeuP patients and HC. (D) Individual participant rsFC values between the right amygdala and the left AG. (E) In male patients with NeuP, pain intensity positively correlated with the right amygdala-right dlPFC rsFC. (F) In female patients with NeuP, pain intensity negatively correlated with the right amygdala-left AG rsFC. (C,D) Data points represent individual values; bars represent mean [SD]. (E,F) Data points represent individual values; solid line represents regression line for correlation; dotted lines represent 95% confidence interval. au, arbitrary units; HC, healthy control; NeuP, neuropathic pain; R, right hemisphere; r, Pearson correlation; ρ, Spearman correlation.