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. 2022 May 27;13:907060. doi: 10.3389/fendo.2022.907060

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Copyright © 2022 Geng, Li and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epitranscriptomic regulatory mechanisms in liver and pancreatic β cells in diabetes mellitus. The green arrow indicates an increase in the change, whereas the red arrow indicates a decrease in the change. METTL3, Methyltransferase-like 3; FTO, Fat mass and obesity-associated protein; PEPCK, Phosphoenolpyruvate arboxynase; FOXO1, Forkhead box O1; ATF4, Activating transcription factor 4; Fasn, Fatty acid synthase; PEPCK, Phosphoenolpyruvate carboxynase; IGF2, Insulin-like growth factor 2; IMP2/IGF2BP2, IGF2 mRNA binding protein 2; PDX1, Pancreatic duodenal homeobox 1; GSK3, Glycogen synthase kinase-3; ROS, Reactive oxygen species; IRE1α, Inositol-requiring enzyme 1 alpha; XBP-1, X-box binding protein spliced.