Skip to main content
. 2022 May 27;13:907060. doi: 10.3389/fendo.2022.907060

Figure 4.

Figure 4

Regulatory roles and possible mechanisms of RNA modifications in the pathogenesis of diabetes-associated complications, including diabetic cardiomyopathy, nephropathy, retinopathy, cataracts, wounds, and neuropathy. The green arrow indicates an increase in the change, whereas the red arrow indicates a decrease in the change. METTL3/14/16, Methyltransferase-like 3, 14, 16; FTO, Fat mass and obesity-associated protein; ALKBH5, ALKB homolog 5; YTHDF2, YT521-B homology (YTH) protein families including YTH domain family 2; YTHDC1, YTH domain containing 1; TINCR: Terminal differentiation-induced noncoding RNA; NLRP3, Nucleotide-binding domain (NBD) and leucine-rich repeat (LRR) pyrin-domain containing protein 3; TIMP2, Tissue inhibitor of metalloproteinases 2; IGF2BPs, Insulin-like growth factor 2 mRNA-binding proteins; HDAC5, Histone deacetylase 5; ITGB1, Integrin β1; KAT1, Lysine acetyltransferase 1; ICAM-1, Intercellular adhesion molecule-1; SQSTM1, Sequestosome 1; VEGF-C, Vascular endothelial growth factor C. HLECs, Human lens epithelial cells; A20, Also known as tumor necrosis factor-a induced protein 3 (TNFAIP3); ALKBH5, ALKB homolog 5.