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. 2022 May 27;16:881480. doi: 10.3389/fnins.2022.881480

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Copyright © 2022 Thrush, Vadukul and Aprile.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Beaded aggregations of WT (blue) and 7–140 (purple) α-syn. WT and 7–140 α-syn have t_1/2 values of 38 ± 7 and 69.7 ± 0.7 h and t_lag values of 28 ± 6 and 31 ± 6 h, respectively. Each data set is the average of the normalized technical replicates (n ≥ 3, error bars are the standard deviation of the mean). Three independent replicates for WT α-syn and two independent replicates for 7–140 α-syn are shown. (B) Dot blots (left) and quantifications (right) of the soluble fractions after aggregation of WT (blue) and 7–140 (purple) α-syn after aggregation (n = 5, values represent means and error bars are the standard deviation, Welch’s t-test ^***p = 0.0002).