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. 2022 May 27;13:793499. doi: 10.3389/fphar.2022.793499

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Copyright © 2022 Zhao, Shen, Li, Dan, Zhao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional differences between colorectal cancer HCT116 cells treated with tadalafil (TAD) and without tadalafil (CON). (A) Venn diagram of transcriptome profiles in TAD and CON groups. Gene expression analysis revealed that 15,430 genes were co-expressed in TAD and CON groups, while 590 and 541 genes were specifically expressed in TAD and CON groups, respectively. (B) Cluster heatmap of differentially expressed genes (DEGs) induced by tadalafil in HCT116 cells; the green to red color scale indicates the value of log2 (FPKM) after scale number. (C) Volcano plot of DEGs; the green indicates downregulated DEGs, and red indicates upregulated DEGs. p-value < 0.05 and FC ≥ 2.