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. 2022 May 27;13:793499. doi: 10.3389/fphar.2022.793499

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Copyright © 2022 Zhao, Shen, Li, Dan, Zhao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analysis of DEGs. (A) Functional enrichment clustering analysis of DEGs was performed by top GO terms in biological process, cellular component, and molecular function. (B) Bubble chart of the KEGG pathways (top 30) that DEGs significantly involved in. The rich factor is defined as the ratio of the number of DEGs to the total number of genes enriched in a specific category. The count of DEGs was roughly represented by the size of circles. Log10-adjusted p-value was indicated by the color saturation from green to red. GO, Gene Ontology; BP, biological processes; CC, cellular components; MF, molecular functions; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEGs, differentially expressed genes. p-value < 0.05.