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. 2022 May 27;13:793499. doi: 10.3389/fphar.2022.793499

FIGURE 4.

FIGURE 4

OPLS-DA analysis of alterations in the metabolite profile. (A) OPLS-DA score plot derived from metabolite ions acquired using the ESI+. (B) OPLS-DA score plot derived from metabolite ions acquired using the ESI-. (C,D) Permutation test for OPLS-DA in positive and negative ion mode. OPLS-DA, orthogonal partial least-squares discriminant analysis; ESI+, electrospray ionization positive ion mode; ESI-, electrospray ionization negative ion mode.