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. 2022 May 27;13:793499. doi: 10.3389/fphar.2022.793499

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Copyright © 2022 Zhao, Shen, Li, Dan, Zhao and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolic differences between colorectal cancer HCT116 cells treated with tadalafil groups (TAD) and without groups (CON). (A,B) Cluster heatmap of DAMs in ESI+ and ESI-. The value of DAMs expression after scale number was indicated by the blue to red color scale. (C,D) Volcano plots of DAMs in ESI+ and ESI−. Red indicates upregulated accumulated metabolites (p-value <0.05, FC > 1.5), and blue indicates downregulated accumulated metabolites (p-value <0.05, FC < 0.67). Black indicates no significant difference of metabolites. (E,F) Pearson correlation analysis of the DAMs based on p < 0.05 and VIP >1 in ESI+ and ESI−. The value of the Pearson correlation coefficient was represented by the color label. ESI+, electrospray ionization positive ion mode; ESI−, electrospray ionization negative ion mode; DAM, differentially accumulated metabolites.