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. 2022 May 25;54:102347. doi: 10.1016/j.redox.2022.102347

Fig. 1.

Fig. 1

scRNA-seq reveals heterogeneity of immune cells in the stroke brain. (A) Experimental design for scRNA-seq (n = 3 per group). Cells in each group were pooled up to 9000 target cells per hemisphere. (B) UMAP plots showing clusters and annotations of cells identified in stroke brains obtained at 24 h and 48 h after tMCAO. (C) Heatmap showing the relative expression levels of the top marker genes in the six cell types identified by scRNA-seq. (D) UMAP plots showing representative markers for each cell cluster in the ischemic brain. (E) UMAP plot showing clusters of each hemisphere cell population at 24 h and 48 h after tMCAO. (F) Stacked bar graphs showing the proportion of cells identified in each cluster out of the total number of cells at 24 h and 48 h after tMCAO. (G) Bar graphs showing total cell numbers identified in clusters of each hemisphere at 24 h and 48 h after tMCAO.