Table 1.

Effects of aging on donor kidney and transplant recipients after kidney transplantation

	Kidney from older donor	Older recipient
Effects	Increased immunogenicity	Reduced numbers of naïve T cells and T regulatory cells
	Increased susceptibility to renal ischemia/reperfusion injury	CD4+ and CD8+ memory T cell dysfunction
	Functional impairment of repair system	Increased cytokine production
	Increased graft atherosclerosis	Increased levels of immunosuppressive agents
	Decreased nephron number	Multiple comorbidity conditions
Results	Increased incidence of acute rejection	Increased patient death
	Increased risk of graft failure	Increased infection-related complications
	Increased risk of delayed graft function	Lower incidence of acute rejection
	Increased transplant vasculopathy	Increased risk of graft failure