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. 2022 Jun 8;221(7):e202108015. doi: 10.1083/jcb.202108015

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© 2022 Wang et al.

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Figure 9. — Spike-lentivirus-ORF10 perturbs cilia biogenesis in multiciliated primary human nasal epithelial cells (HNECs). (A) Spike-lentivirus-ORF10 perturbs cilia biogenesis in multiciliated primary human nasal epithelial cells (HNECs). Confocal imaging of mock, Spike-lentivirus, and Spike-lentivirus-ORF10 infected epithelium for 2 dpi (days post infection). (B) Quantification ratio of ciliated area in A (n = 5 independent experiments). Data are presented as the mean ± SEM. *** indicates P < 0.001. Statistical analysis was performed with two-tailed unpaired Student’s t test. (C) The model of the effect of SARS-CoV-2 infection on the ciliated cell. Source data are available for this figure: SourceData F9.