Table 3.
Differences between single-nucleotide polymorphisms in depressive and anxiety symptoms, separately analyzed with ANOVA using the dominant model and the recessive model
|
Models
|
Mental symptoms
|
SNPs
|
Total
|
Sex
|
IBS subtypes
|
|||
|
Male
|
Female
|
IBS-C
|
IBS-D
|
IBS-M
|
||||
| Dominant model | Depressive symptoms | HTR3A c.-42C>T (rs1062613) | 2.541 | 4.149 ↑ | 0286 | 0.998 | 0.376 | 0.694 |
| HTR3B c.386A>C (rs1176744) | 0.067 | 0.005 | 0.198 | 0.282 | 0.124 | 0.232 | ||
| HTR3C c.489C>A (rs6766410) | 7.475 ↑ | 0.672 | 7.040 ↑ | 0.261 | 5.670 ↑ | 2.328 | ||
| HTR3E c.*76G>A (rs62625044) | 0.054 | 0.013 | 0.180 | 0.208 | 0.461 | 0.010 | ||
| Anxiety symptoms | HTR3A c.-42C>T (rs1062613) | 0.511 | 0.210 | 0.280 | 0.604 | 0.672 | 0.162 | |
| HTR3B c.386A>C (rs1176744) | 0.926 | 0.406 | 0.801 | 0.468 | 1.369 | 0.770 | ||
| HTR3C c.489C>A (rs6766410) | 6.535 ↑ | 0.158 | 7.550 ↑ | 0.186 | 13.444 ↑ | 0.045 | ||
| HTR3E c.*76G>A (rs62625044) | 1.055 | 0.429 | 0.853 | 0.000 | 0.495 | 1.109 | ||
| Somatization symptoms | HTR3A c.-42C>T (rs1062613) | 0.016 | 0.141 | 0.106 | 0.086 | 0.017 | 0.203 | |
| HTR3B c.386A>C (rs1176744) | 0.217 | 0.332 | 0.326 | 0.407 | 0.415 | 2.125 | ||
| HTR3C c.489C>A (rs6766410) | 0.784 | 0.035 | 1.085 | 0.269 | 0.000 | 1.962 | ||
| HTR3E c.*76G>A (rs62625044) | 0.002 | 1.554 | 0.263 | 0.128 | 0.729 | 0.354 | ||
| Recessive model | Depressive symptoms | HTR3A c.-42C>T (rs1062613) | 0.002 | 0.421 | 0.132 | 0.093 | 1.320 | 1.064 |
| HTR3B c.386A>C (rs1176744) | 1.118 | 2.027 | 0.107 | 1.741 | 0.197 | 0.744 | ||
| HTR3C c.489C>A (rs6766410) | 0.047 | 0.821 | 0.401 | 2.306 | 6.190 ↑ | 0.676 | ||
| HTR3E c.*76G>A (rs62625044) | 0.677 | - | 0.574 | 0.541 | - | - | ||
| Anxiety symptoms | HTR3A c.-42C>T (rs1062613) | 0.479 | 0.027 | 0.549 | 0.057 | 0.315 | 0.350 | |
| HTR3B c.386A>C (rs1176744) | 0.872 | 0.081 | 1.691 | 0.476 | 0.361 | 1.923 | ||
| HTR3C c.489C>A (rs6766410) | 0.028 | 2.562 | 0.344 | 0.570 | 3.509 | 2.093 | ||
| HTR3E c.*76G>A (rs62625044) | 0.216 | - | 0.179 | 0.242 | - | - | ||
| Somatization symptoms | HTR3A c.-42C>T (rs1062613) | 0.217 | 0.018 | 0.257 | 0.138 | 0.092 | 0.431 | |
| HTR3B c.386A>C (rs1176744) | 6.482 ↑ | 2.245 | 3.575 | 0.142 | 14.033 ↑ | 0.341 | ||
| HTR3C c.489C>A (rs6766410) | 0.468 | 1.813 | 0.128 | 4.715 ↓ | 0.002 | 0.113 | ||
| HTR3E c.*76G>A (rs62625044) | 0.001 | - | 0.011 | 0.000 | - | - | ||
F values are shown in the table. Arrows represent the direction of the associations. ↑ dependent variable increases from major to minor alleles; ↓ dependent variable decreases from major to minor alleles. The underlined values were significant. Values in bold were “nominally significant” (i.e., lacking significance after false discovery rate multiple testing correction). IBS: Irritable bowel syndrome; IBS-C: Constipation-predominant IBS; IBS-D: Diarrhea-predominant IBS; IBS-M: IBS with mixed bowel habits; SNPs: Single-nucleotide polymorphisms.