Table 4.
Association of depressive, anxiety, and somatization symptoms with the single-nucleotide polymorphism score of the four tested polymorphisms
|
|
Total
|
Sex
|
IBS subtypes
|
|||
|
Male
|
Female
|
IBS-C
|
IBS-D
|
IBS-M
|
||
| Depressive symptoms | ||||||
| F value | 7.710 | 1.336 | 5.770 | 1.551 | 2.159 | 0.196 |
| P-linear trend value | 0.006 | 0.250 | 0.017 | 0.184 | 0.144 | 0.659 |
| Anxiety symptoms | ||||||
| F value | 2.150 | 0.028 | 2.514 | 1.372 | 2.400 | 1.412 |
| P-linear trend value | 0.143 | 0.866 | 0.114 | 0.245 | 0.123 | 0.236 |
| Somatization symptoms | ||||||
| F value | 1.15 | 0.354 | 1.028 | 0.716 | 2.718 | 0.628 |
| P-linear trend value | 0.283 | 0.553 | 0.311 | 0.614 | 0.102 | 0.429 |
Values in bold were “nominally significant” (i.e., lacking significance after false discovery rate multiple testing correction). IBS: Irritable bowel syndrome; IBS-C: Constipation-predominant IBS; IBS-D: Diarrhea-predominant IBS; IBS-M: IBS with mixed bowel habits.