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. 2022 Jun 7;28(21):2320–2333. doi: 10.3748/wjg.v28.i21.2320

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Amplicon sequence variants contributing to the changes in the gut microbiota in groups healthy control, type 2 diabetes mellitus, and type 2 diabetes mellitus plus obstructive sleep apnea. A: The heatmap shows the relative abundance of the 46 amplicon sequence variants (ASVs) significantly different in the three groups. The fold ratio (log2-transformed) indicated the relative abundance of the 46 ASVs between the two different groups [P1: Type 2 diabetes mellitus (T2DM) + obstructive sleep apnea (OSA) vs T2DM; P2: T2DM + OSA vs healthy control (HC); P3: HC vs T2DM]. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. Significant difference shown by the Mann–Whitney U test; B: With the increase in disease components, six key ASVs showed increasing or decreasing trends. ^aP < 0.05, ^bP < 0.01.